6-Fluoro-2,3,4,5-tetrahydro-1H-pyrido-[4,3-b]indole hydrochloride synthesis
- Product Name:6-Fluoro-2,3,4,5-tetrahydro-1H-pyrido-[4,3-b]indole hydrochloride
- CAS Number:177858-77-4
- Molecular formula:C11H11FN2
- Molecular Weight:190.22
2924-15-4
292 suppliers
$6.00/5g
79099-07-3
544 suppliers
$5.00/5g
177858-77-4
12 suppliers
$764.02/1G
Yield:177858-77-4 75%
Reaction Conditions:
with sulfuric acid at 0 - 100; for 4 h;
Steps:
6.A Step A
To a solution of commercially available (2-fluorophenyl)hydrazine hydrochloride (2 g, 12.34 mmol) and tert-butyl 4-oxopiperidine-1 -carboxylate (2.45 g, 12.34 mmol) in dioxane (20 ml_) was added concentrated H2SO4 (2 ml_), 0 °C. Then the reaction mixture was heated at 100°C for 4 h. After completion of the reaction (monitored by TLC), the reaction mixture was cooled to 25 °C and then concentrated. The crude mixture was basified by 10% NaOH solution and the precipitate was filtered off. The solid was washed with water and dried under vacuum to get the title compound (1 .7 g, 75%).MS: 191 .0 (M+H)+.
References:
WO2020/177952,2020,A1 Location in patent:Page/Page column 40; 41
41979-39-9
122 suppliers
$15.00/10mg
2924-15-4
292 suppliers
$6.00/5g
177858-77-4
12 suppliers
$764.02/1G