5-Bromo-1,3-dihydro-isoindole-2-carboxylic acid benzyl ester synthesis
- Product Name:5-Bromo-1,3-dihydro-isoindole-2-carboxylic acid benzyl ester
- CAS Number:178445-27-7
- Molecular formula:C16H14BrNO2
- Molecular Weight:332.19
919346-89-7
123 suppliers
$26.00/250mg
501-53-1
410 suppliers
$10.00/1g
178445-27-7
11 suppliers
inquiry
Yield:178445-27-7 1.1 g
Reaction Conditions:
with triethylamine in dichloromethane at 20; for 1 h;Cooling with ice;
Steps:
3.1 Step 1: preparation of benzyl 5-bromoisoindoline-2-carboxylate (compound 3a)
To a flask was added 5-bromoisoindoline hydrochloride (CAS: 919346-89-7, Vendor: PharmaBlock, 1.00 g, 4.26 mmol), TEA (1.29 g, 1.78 mL, 12.80 mmol) and DCM (20 mL). Then it was cooled with ice bath and Cbz-Cl (873 mg, 730 pL, 5.12 mmol) was added dropwise. After being stirred at rt for 1 h, the mixture was diluted with water (20 mL) and extracted with EA (20 mL) twice. The combined organic layer was dried over Na2S04 and concentrated to give a brown oil which was purified by flash column (EA/PE = 0 to 20%) to give compound 3a (1.10 g) as a white solid. MS: calc’d 332, 334 (MH+), measured 332, 334 (MH+).
References:
WO2019/238616,2019,A1 Location in patent:Page/Page column 57-58
110-54-3
827 suppliers
$20.00/100ml
501-53-1
410 suppliers
$10.00/1g
178445-27-7
11 suppliers
inquiry
501-53-1
410 suppliers
$10.00/1g
127168-84-7
116 suppliers
$65.00/0.1g
178445-27-7
11 suppliers
inquiry
583-71-1
175 suppliers
$13.43/1gm:
178445-27-7
11 suppliers
inquiry
69189-19-1
65 suppliers
$43.00/250mg
178445-27-7
11 suppliers
inquiry