ChemicalBook CAS DataBase List N-prop-2-yn-1-ylcyclohexanamine(SALTDATA: HCl 0.1H2O)

N-prop-2-yn-1-ylcyclohexanamine(SALTDATA: HCl 0.1H2O) synthesis

8synthesis methods

Product Name:N-prop-2-yn-1-ylcyclohexanamine(SALTDATA: HCl 0.1H2O)
CAS Number:18292-76-7
Molecular formula:C9H15N
Molecular Weight:137.22

108-91-8 Synthesis

108-91-8
632 suppliers
$10.00/5mL

106-96-7 Synthesis

106-96-7
343 suppliers
$31.00/25g

N-prop-2-yn-1-ylcyclohexanamine(SALTDATA: HCl 0.1H2O)

18292-76-7
15 suppliers
$432.00/1g

Yield:18292-76-7 85%

Reaction Conditions:

with potassium carbonate in N,N-dimethyl-formamide at 20; for 5 h;Inert atmosphere;

Steps:

General procedure for the preparation of compound 1

General procedure: Propargyl bromide (1.2 mmol for the preparation of 1a, 1c, 1d, 1e and 2.0 mmol for the preparation of 1b) was added to a solution of alkyl/aryl amine (1.0 mmol) and potassium carbonate (3.0 mmol) in DMF (25 mL) under a nitrogen atmosphere. The mixture was stirred at room temperature for 5 h. After completion (confirmed by TLC), the mixture was diluted with ice-water (60 mL) and extracted with ethyl acetate (3 x 15 mL). The organic layers were collected, combined, dried over anhydrous Na₂SO₄, filtered and concentrated under low vacuum. The residue was purified by column chromatography using hexane and EtOAc as eluent to afford the title compound.

References:

Sujeevan Reddy, Gangireddy;Babu Nallapati, Suresh;Sri Saranya;Sridhar;Bhat Giliyaru, Varadaraj;Chandrashekhar Hariharapura, Raghu;Gautham Shenoy;Pal, Manojit [Tetrahedron Letters,2018,vol. 59,# 52,p. 4587 - 4592] Location in patent:supporting information