1-Piperidinecarboxylic acid, 4-(Methylsulfonyl)-, 1,1-diMethylethyl ester synthesis
- Product Name:1-Piperidinecarboxylic acid, 4-(Methylsulfonyl)-, 1,1-diMethylethyl ester
- CAS Number:189205-49-0
- Molecular formula:C11H21NO4S
- Molecular Weight:263.35
208245-69-6
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189205-49-0
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Yield:189205-49-0 92%
Reaction Conditions:
with 3-chloro-benzenecarboperoxoic acid in dichloromethane at 0 - 20;
Steps:
14.1
To a solution of tert-butyl 4-(methylthio)piperidine- 1 -carboxylate (280 mg, 1.2 mmol) (reagent preparation 12, step 2) in dichloromethane (8 mL) was added m-chloroperbenzoic acid (835 mg, 4.8 mmol) at 0 0C. The solution was warmed to room temperature and stirred for 15 h. The reaction mixture was partitioned between IN sodium hydroxide and ethyl acetate. The organic layer was washed with brine, dried over sodium sulfate, filtered and concentrated to give tert-butyl 4-(methylsulfonyl)piperidine-l- carboxylate (290 mg, 92% yield). MS (EI) for CnH2iNO4S: 206 (M-tBu+).
References:
WO2010/138487,2010,A1 Location in patent:Page/Page column 123
109384-19-2
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189205-49-0
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