
1H-Benzimidazole-2-methanol,alpha-methyl-,(alphaS)-(9CI) synthesis
- Product Name:1H-Benzimidazole-2-methanol,alpha-methyl-,(alphaS)-(9CI)
- CAS Number:192316-22-6
- Molecular formula:C9H10N2O
- Molecular Weight:162.19
Yield:192316-22-6 90%
Reaction Conditions:
with hydrogenchloride in water; for 1.66667 h;Heating / reflux;
Steps:
18 Example 18; Preparation of Compound (33)
Example 18 Preparation of Compound (33) Compound (33) was prepared according to the method of Scheme 3. 1,2-diaminobenzene (10.81 g, 0.1 mol) and (2S)-2-hydroxypropanoic acid (15.90 g, 85+% in water from Aldrich, 0.15 mol) were mixed in 100 ml of 6 N HCl and refluxed for 100 minutes. Cooled down in ice bath, the reaction mixture was neutralized with aqueous NH3 solution. The precipitate was collected by filtration, washed with water, and then vacuum dried. The intermediate (1S)-1-(1H-benzimidazol-2-yl)ethanol (14.52 g) was obtained in 90% yield.
References:
US2005/148643,2005,A1 Location in patent:Page/Page column 29