ChemicalBook CAS DataBase List 1H-Benzimidazol-5-ylmethanol

1H-Benzimidazol-5-ylmethanol synthesis

6synthesis methods

Product Name:1H-Benzimidazol-5-ylmethanol
CAS Number:106429-29-2
Molecular formula:C8H8N2O
Molecular Weight:148.16

15788-16-6
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$5.00/250mg

106429-29-2
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$45.00/50mg

Yield:106429-29-2 77%

Reaction Conditions:

with lithium aluminium tetrahydride in tetrahydrofuran at 65; for 48 h;Inert atmosphere;

Steps:

Preparation of compounds 7-10
Preparation of compounds 7-10
To a suspension of 2.0 g (12.3 mmol) of 1H-benzo[d]imidazole-5-carboxylic acid in 50 mL of dry THF, in inert atmosphere was added 983 mg (24,7 mmol) of LiAlH₄ and stirred 48 h at 65 °C.
The reaction mixture was poured into EtOAc/EtOH and was filtered, by evaporation to dryness 1.4 g (77%) of compound 7 was obtained.

References:

Álvarez, Raquel;Gajate, Consuelo;Puebla, Pilar;Mollinedo, Faustino;Medarde, Manuel;Peláez, Rafael [European Journal of Medicinal Chemistry,2018,vol. 158,p. 167 - 183]

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141-78-6 Synthesis