ChemicalBook CAS DataBase List Tris(hydroxymethyl)nitromethane

Tris(hydroxymethyl)nitromethane synthesis

9synthesis methods

Product Name:Tris(hydroxymethyl)nitromethane
CAS Number:126-11-4
Molecular formula:C4H9NO5
Molecular Weight:151.12

Tris(hydroxymethyl)nitromethane is prepared by the condensation of nitromethane and formaldehyde under basic conditions.

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Yield:-

Reaction Conditions:

with triethylamine at 45 - 50; for 1 h;

Steps:

2
Conversion of nitromethane (NM) to tris(hydroxymethyl)nitromethane (TN).5 equivalents of methyl formcel are charged to the reaction flask. The reaction is catalyzed with 0.4 mole % triethylamine (TEA), which is added to the methyl formcel. NM (1.0 molar eq.) is fed into this mixture at such a rate so as to keep the temperature between 45 - 50°C. Once the NM has been added, the reaction mixture is stirred for an additional hour. During this time, no external cooling is applied and the temperature will drop slowly.

References:

ANGUS CHEMICAL COMPANY;MOORE, David W.;SWEDO, Raymond;PEERA, Asghar A. WO2012/44508, 2012, A1 Location in patent:Page/Page column 13

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50-00-0 Synthesis