1H-Pyrazole,3,5-dimethyl-1-(4-nitrophenyl)- synthesis
- Product Name:1H-Pyrazole,3,5-dimethyl-1-(4-nitrophenyl)-
- CAS Number:13788-94-8
- Molecular formula:C11H11N3O2
- Molecular Weight:217.22
100-16-3
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123-54-6
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$10.00/25ml
13788-94-8
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$30.00/20mg
Yield:13788-94-8 97%
Reaction Conditions:
in lithium hydroxide monohydrate;propane-1,2,3-triol at 90; for 0.5 h;Green chemistry;
Steps:
General procedure: General procedure: Glycerol (2 mL) was dissolved inwater (2 mL), then phenylhydrazine derivative (1 mmol) wasadded under stirring and the reaction mixture was heated to90 °C followed by addition of 1,3-dicarbonyl compounds(1 mmol). The progress of reaction was monitored by TLC.When all the starting material had been consumed, the mixturewas cooled to room temperature and extracted with ethylacetate (2 × 5 mL). The organic phase was separated and driedover anhydrous Na2SO4 and evaporated under reduced pressureto give crude product. The pure product was isolated by silicagel column chromatography to give the product as a yellowoil or powder.
References:
Min, Zhen-Li;Zhang, Qian;Hong, Xing;Cao, Xiao-Lu;Hu, Xia-Min [Asian Journal of Chemistry,2015,vol. 27,# 9,p. 3205 - 3207]
636-99-7
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123-54-6
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$10.00/25ml
13788-94-8
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$30.00/20mg
1118-66-7
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$5.00/250mg
100-16-3
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$45.00/1g
13788-94-8
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$30.00/20mg
67-51-6
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350-46-9
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13788-94-8
22 suppliers
$30.00/20mg