2'-(1-Piperidinyl)acetophenone synthesis
- Product Name:2'-(1-Piperidinyl)acetophenone
- CAS Number:39911-06-3
- Molecular formula:C13H17NO
- Molecular Weight:203.28
110-89-4
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39911-06-3
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Yield:39911-06-3 94.2%
Reaction Conditions:
with potassium carbonate in dimethyl sulfoxide at 100; for 16 h;
Steps:
34.1 Step 1
To a stirred solution of compound 2 ’-Fluoro acetophenone (30 g, 0.22 mol, 1 eq) and piperidine (19.6 g, 0.23 mol, 1.05 eq) in DMSO (200 mL) was added K2CO3 (45.5 g, 0.33 mol, 1.5 eq). The reaction was stirred at 100 °C for 16 h. TLC showed the reaction was completed. The mixture was cooled to room temperature and poured into water (1 L), extracted with ethyl acetate (400 mL*4). The combined organic layers were washed with brine (300 mLX3), dried with Na2SO4, filtered and concentrated in vacuum to give compound 34A (42 g, Y=94.2%) as a yellow oil, which was used directly for the next step without further purification.
References:
WO2022/76383,2022,A1 Location in patent:Paragraph 00291
110-89-4
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$15.96/100ML
39911-06-3
16 suppliers
$175.00/500mg
98-86-2
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$9.00/5g
39911-06-3
16 suppliers
$175.00/500mg
