2-(1H-indol-3-yl)acetaldehyde synthesis
- Product Name:2-(1H-indol-3-yl)acetaldehyde
- CAS Number:2591-98-2
- Molecular formula:C10H9NO
- Molecular Weight:159.18
526-55-6
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Yield:2591-98-2 91%
Reaction Conditions:
with 2-iodoxybenzoic acid in acetonitrile at 80; for 3 h;
Steps:
16.1 Step 1: Synthesis of 2-(lH-indol-3-yl)acetaldehyde
To a solution of 2-(1Η- indol-3-yl)ethan-l-ol (1.00 g, 6.20 mmol) in CH3CN (25 mL) was added 2-iodoxybenzoic acid (0.52 g, 18.0 mmol). The reaction mixture was heated at 80 °C for 3 h. The reaction mixture was filtered through a pad of diatomaceous earth, washing with CH3CN (10 mL). The filtrate was concentrated in vacuo to afford 2-(lH-indol-3-yl) acetaldehyde (0.90 g, 91%) as a brown semi solid. This compound was used as such for the next reaction without further purification.
References:
WO2017/20010,2017,A1 Location in patent:Paragraph 0144
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