2-(1H-PYRAZOL-3-YL)PYRIDINE synthesis
- Product Name:2-(1H-PYRAZOL-3-YL)PYRIDINE
- CAS Number:75415-03-1
- Molecular formula:C8H7N3
- Molecular Weight:145.16
75415-00-8
75415-03-1
Example 15 Synthesis of 2-(1H-pyrazol-3-yl)pyridine (17a): compound 16a (1 g, 6.2 mmol) was dissolved with hydrazine hydrate (2 mL) in ethanol (3.3 mL) and reacted at 60°C for 0.5 hrs. Upon completion of the reaction, the mixture was cooled to room temperature and the solvent was subsequently removed under vacuum to afford the pale yellow solid product 17a (874.7 mg) in 97.3% yield.1H-NMR (400 MHz, CDCl3): δ 8.66 (d, J = 4.8 Hz, 1H), 7.75 (d, J = 3.6 Hz, 2H), 7.67 (d, J = 2Hz, 1H), 7.23-7.27 (m, 1H), 6.81 (d, J = 2Hz, 1H).
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Yield:75415-03-1 97.3%
Reaction Conditions:
with hydrazine hydrate in ethanol at 60; for 0.5 h;
Steps:
15 Synthesis of 2-(3-pyrazolyl)pyridine (17a)
Example 15
Synthesis of 2-(3-pyrazolyl)pyridine (17a)
Compound 16a (1 g, 6.2 mmol) obtained from the aforesaid process and hydrazine hydrate (2 mL) were dissolved in ethanol (3.3 mL), and reacted at 60° C. for 0.5 hour.
Then, the mixture was cooled to room temperature, and then the solvent was removed in vacuum to afford the product 17a (874.7 mg) as a faint yellow solid, with a yield of 97.3%.
1H-NMR (400 MHz, CDCl3): δ 8.66 (d, J=4.8 Hz, 1H), 7.75 (d, J=3.6 Hz, 2H), 7.67 (d, J=2 Hz, 1H), 7.23-7.27 (m, 1H), 6.81 (d, J=2 Hz, 1H).
References:
SI CHUAN UNIVERSITY;SICHUAN GOODDOCTOR PHARMACEUTICAL GROUP CO., LTD;Luo, Youfu;Wang, Zhenling;Wei, Yuquan;Geng, Funeng US2014/142144, 2014, A1 Location in patent:Paragraph 0235; 0236; 0237
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75415-03-1
154 suppliers
$12.00/250mg
1122-62-9
574 suppliers
$7.00/10g
75415-03-1
154 suppliers
$12.00/250mg