2-PYRAZOL-1-YL-PYRIDINE synthesis
- Product Name:2-PYRAZOL-1-YL-PYRIDINE
- CAS Number:25700-11-2
- Molecular formula:C8H7N3
- Molecular Weight:145.16
288-13-1
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1120-90-7
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25700-11-2
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$23.00/250mg
Yield: 94%
Reaction Conditions:
with copper(l) iodide;manganese(II) fluoride;(1R,2R)-1,2-diaminocyclohexane;potassium hydroxide in water at 100; for 48 h;
Steps:
General procedure for N-arylation of nitrogen nucleophiles
General procedure: The N-nucleophile (1.47 mmol), CuI (Sigma-Aldrich, 99.999% purity, 0.147 mmol), MnF2 (Sigma-Aldrich, 98% purity, 0.441 mmol), KOH (2.94 mmol), the aryl halide (2.21 mmol), trans-1,2-diaminocyclohexane (0.294 mmol) and water (0.75 mL) were added to a reaction vial and a screw cap was fitted to it. The reaction mixture was stirred under air in a closed system at 60C for 24 h. After cooling to room temperature, the mixture was diluted with dichloromethane and filtered through a pad of Celite. The combined organic extracts were dried with anhydrous Na2SO4 and the solvent was removed under reduced pressure. The crude product was purified by silica-gel column chromatography to afford the N-arylated product. The identity and purity of known products was confirmed by 1H and 13C NMR spectroscopic analysis.
References:
Teo, Yong-Chua;Yong, Fui-Fong;Lim, Gina Shiyun [Tetrahedron Letters,2011,vol. 52,# 52,p. 7171 - 7174] Location in patent:supporting information; experimental part
288-13-1
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109-04-6
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25700-11-2
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$23.00/250mg
288-13-1
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5029-67-4
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25700-11-2
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288-13-1
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109-09-1
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25700-11-2
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$23.00/250mg
4930-98-7
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102-52-3
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25700-11-2
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$23.00/250mg