2,2,2-Trifluoroethylamine hydrochloride synthesis
- Product Name:2,2,2-Trifluoroethylamine hydrochloride
- CAS Number:373-88-6
- Molecular formula:C2H5ClF3N
- Molecular Weight:135.52
753-90-2
373-88-6
General procedure for the synthesis of 2,2,2-trifluoroethylamine hydrochloride from 2,2,2-trifluoroethylamine: 100 g of ethanol and 33 g of 2,2,2-trifluoroethylamine were added to a triple-necked flask, and 35 g of saturated hydrochloric acid solution was added slowly and dropwise at temperatures lower than 25°C. The reaction system was then brought up to 50°C and maintained there for 1 hour. After the dropwise addition, the temperature of the reaction system was raised to 50 °C and maintained for 1 hour. Subsequently, the temperature of the reaction solution was controlled to be 45±5°C under a vacuum of 0.98 MPa and a decompression distillation was carried out for 5 hours to remove water and ethanol. Finally 43.5 g of 2,2,2-trifluoroethylamine hydrochloride was obtained in 96.30% yield. The resulting product was a white powdery crystalline solid with 0.13% water.
753-90-2
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373-88-6
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Yield:373-88-6 96.3%
Reaction Conditions:
with hydrogenchloride in ethanol;water at 25 - 50; for 1 h;Temperature;
Steps:
2
Add 100 g to a three-necked flaskEthanol and 33 gTrifluoroethylamine,At temperatures below 25 ° C, 35 g of saturated hydrochloric acid solution was slowly added dropwise,After the drop was completed, the temperature was raised to 50 ° C for one hour.The reaction solution in the system after the vacuum of 0.98MPa,The control temperature is 45 ± 5 ° C,After 5 hours of distillation under reduced pressure, the water and ethanol were removed,To give trifluoroethylamine hydrochloride 43. 5 g,The product yield was 96. 30%. The obtained trifluoroethylamine hydrochloride was a white powdery crystalline solid,The water content was 0.13%.
References:
CN105801428,2016,A Location in patent:Paragraph 0016; 0017
354-38-1
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373-88-6
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373-88-6
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