2-(2-Bromophenyl)-2-propanol synthesis
- Product Name:2-(2-Bromophenyl)-2-propanol
- CAS Number:7073-69-0
- Molecular formula:C9H11BrO
- Molecular Weight:215.09
610-94-6
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$13.00/25g
75-16-1
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$12.00/10ml
7073-69-0
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$22.00/250mg
Yield: 98.2%
Reaction Conditions:
Stage #1:2-bromobenzoic acid methyl ester;methylmagnesium bromide in tetrahydrofuran at 20;Cooling with ice;
Stage #2: with hydrogenchloride in water; pH=5 - 6
Steps:
2 Example 2: Preparation of compound II (taking methyl 2-bromobenzoate as an example)
Methyl 2-bromobenzoate (226g, 1.05mol) was dissolved in THF (1.6L), and 3MCH3MgBr (1.05L, 3.15mol) was added dropwise under ice-water bath conditions. After the addition was completed, a white syrupy liquid was formed. Slowly rise to room temperature and stir until the reaction is complete. Under ice-water bath conditions, use HCl (4.5L, 0.5 M, 2.25mol) to quench the reaction slowly. After the addition is complete, continue to stir for 0.5h, then add 2N HCl (0.5 L, 1.00mol) to make the pH value 5-6 . Add MTBE (1L), separate the organic phase, extract the aqueous phase with MTBE (2×0.5L), combine the organic phases, wash with sodium bicarbonate solution (2×0.3L), dry with anhydrous sodium sulfate, filter, and concentrate , 222 g (98.2% yield) of compound II was obtained as a solid.
References:
CN112430177, 2021, A Location in patent:Paragraph 0067; 0068
917-64-6
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6091-64-1
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$10.00/1g
7073-69-0
84 suppliers
$22.00/250mg
67-64-1
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$17.30/10ml
583-53-9
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$10.00/5g
7073-69-0
84 suppliers
$22.00/250mg
6091-64-1
176 suppliers
$10.00/1g
676-58-4
296 suppliers
$15.00/25ml
7073-69-0
84 suppliers
$22.00/250mg
610-94-6
309 suppliers
$13.00/25g
676-58-4
296 suppliers
$15.00/25ml
7073-69-0
84 suppliers
$22.00/250mg