2,2-Dichloropropanoyl chloride synthesis
- Product Name:2,2-Dichloropropanoyl chloride
- CAS Number:26073-26-7
- Molecular formula:C3H3Cl3O
- Molecular Weight:161.41
75-99-0
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Yield:26073-26-7 92%
Reaction Conditions:
with thionyl chloride in N-methyl-acetamide;
Steps:
1.B B.
B. 2,2-Dichloropropionyl Chloride To a dry 100 mL 3-necked flask under nitrogen were added 2,2-dichloropropionic acid (50 g., 0.35 moles, 1 eq.) and dimethylformamide (4 mL, 0.05 moles, 0.15 eq.). Thionyl chloride (35 mL, 0.49 moles, 1.4 eq.) then was added dropwise over 30 minutes. The reaction mixture was warmed to 55° C. for two hours while being following by gas chromatography with methanol quench to insure disappearance of dichloropropionic acid (retention time 8.5 minutes). 2,2-dichloropropionyl chloride was distilled at 120°-121° C. to give 51.7 g. (92% yield) of a slightly yellow oil.
References:
US5424454,1995,A
127-20-8
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75-89-8
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79-03-8
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27313-32-2
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