2,2-dimethoxy-1-phenylethanone synthesis
- Product Name:2,2-dimethoxy-1-phenylethanone
- CAS Number:6956-56-5
- Molecular formula:C10H12O3
- Molecular Weight:180.2
Yield:6956-56-5 96%
Reaction Conditions:
with sodium carbonate at 80; for 12 h;Green chemistry;
Steps:
7 Example 7
Add 1.88g (10mmol) 2,2-dichloro-acetophenone, 20mL methanol, 3.18g sodium carbonate to the flask, stir the reaction at 80 , the reaction is monitored by TLC, the reaction is complete in about 12h, cool to room temperature, The solid was filtered off and the solid was washed twice with 2 × 10 mL of methanol. The filtrate and washing liquid were combined and concentrated under reduced pressure to obtain a crude product. The GC detection purity was 98.0%, and the silica gel column was separated to obtain 1.73 g of 2,2-dimethoxyacetophenone with a yield of 96%.
References:
CN110963907,2020,A Location in patent:Paragraph 0017
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