ChemicalBook CAS DataBase List 2,2-Dimethylthiopropionamide

2,2-Dimethylthiopropionamide synthesis

2synthesis methods

Product Name:2,2-Dimethylthiopropionamide
CAS Number:630-22-8
Molecular formula:C5H11NS
Molecular Weight:117.21

To a round bottom flask (250 mL) was added trimethyl amine (5.0 g, 0.049 mol) and Lawesson's reagent (8.0g, 0.020 mol), dissolved in THF (100 mL), nitrogen, 80° C oil. The reaction bath for 4 hours. TLC monitors the reaction progress. After completion of the reaction, the solvent was removed by rotary evaporation; the residue was purified by silica gel column chromatography (petroleum ether: 1: ethyl acetate = 10) to give a white solid 2,2-Dimethylthiopropionamide (3.7 g, 65percent yield).

754-10-9 Synthesis

754-10-9
166 suppliers
$7.00/5g

630-22-8
123 suppliers
$8.00/250mg

Yield:630-22-8 65%

Reaction Conditions:

with Lawessons reagent in tetrahydrofuran at 80; for 4 h;Inert atmosphere;

Steps:

4.1 Preparation of thio-2,2-dimethyl-propanamide
To a round bottom flask (250 mL) was added trimethyl amine (5.0 g, 0.049 mol) and Lawesson's reagent (8.0g, 0.020 mol), dissolved in THF (100 mL), nitrogen, 80° C oil The reaction bath for 4 hours.The reaction progress monitored by TLC.After completion of the reaction, the solvent was removed by rotary evaporation, the residue was purified by silica gel column chromatography (petroleum ether: 1: ethyl acetate = 10) to give a white solid (3.7 g, 65% yield).

References:

Tonghua Jida Pharmaceutical Co., Ltd.;Wu, yongqian CN103936728, 2016, B Location in patent:Paragraph 0211; 0213; 0214; 0215

FullText

630-18-2 Synthesis

630-18-2
171 suppliers
$10.00/1g

630-22-8
123 suppliers
$8.00/250mg

References