2-[(2-OXO-2-PHENYLETHYL)THIO]BENZOIC ACID synthesis
- Product Name:2-[(2-OXO-2-PHENYLETHYL)THIO]BENZOIC ACID
- CAS Number:25803-71-8
- Molecular formula:C15H12O3S
- Molecular Weight:272.32
147-93-3
466 suppliers
$7.00/5g
70-11-1
299 suppliers
$10.00/25g
25803-71-8
13 suppliers
$45.00/50mg
Yield:25803-71-8 99.1%
Reaction Conditions:
with sodium acetate in methanol at 20; for 1 h;
Steps:
I.A
I. Preparation of the compounds of the formula (I); The starting materials used are known products or are prepared according to known processes. A-Example of the preparation of a compound of the formula (I) Preparation of (3-hydroxybenzo [b] th iophen-2-yl) phenylmethan one; 32.250 g (0.162 mol) of 2-bromoacetophenone and 13.290 g (0.162 mol) of sodium acetate are added to 25 g (0.162 mol) of thiosalicylic acid C7H602S in 200 mi of methanol. The reaction is stirred for one hour at room temperature. The mixture is diluted with water and the compound is filtered off, washed with water and dried to give 44.0 g (0.160 mol, 99. 1%) of a white solid (used without further purification for the following step). 26.580 g (0.324 mol) of sodium acetate are added to 44 g (0. 162 mol) of the crude product in 200 ml of DMF. The reaction is refluxed for 30 min. The mixture is diluted with water and the precipitate formed is washed with water and dried under vacuum to give 36. 1 g of a white solid (0.141 mol, 88%) of the cyclized compound C5H1002S.
References:
WO2005/54226,2005,A1 Location in patent:Page/Page column 17-18
