ChemicalBook CAS DataBase List N-Phenyldiethanolamine

N-Phenyldiethanolamine synthesis

12synthesis methods

Product Name:N-Phenyldiethanolamine
CAS Number:120-07-0
Molecular formula:C10H15NO2
Molecular Weight:181.23

N-Phenyldiethanolamine is obtained by the addition of aniline and ethylene oxide.

591-50-4 Synthesis

591-50-4
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$10.00/1g

111-42-2
806 suppliers
$10.00/20mg

120-07-0
299 suppliers
$5.00/25g

Yield:120-07-0 95%

Reaction Conditions:

with potassium hydroxide in dimethyl sulfoxide at 100; for 3 h;

Steps:

2.3. General procedure for the N-arylation of imidazole with aryl halides
General procedure: A mixture of aryl halide (1.0 mmol), Het-NH (1.2mmol) or amine (4 mmol), KOH (2 mmol), Cu₂O/nano-CuFe₂O₄ magnetic composite (0.010 g) and anhydrous DMSO (2 mL) was stirred at 100 °C. After completion of the reaction as indicated by TLC, the reaction mixture was cooled to room temperature and with diluted ethyl acetate and the catalyst was separated by an external magnet from the mixture, washed with acetone, dried in an oven at 80 °C for 3 h and re-used for a consecutive run under the same reaction conditions. The combined ethyl acetate layer was washed with water, dried over anhydrous MgSO₄, The residue was purified by recrystallization or short column chromatography on silica gel to afford the target products in excellent yield.

References:

Elhampour, Ali;Nemati, Firouzeh;Kaveh, Mahdieh [Chemistry Letters,2016,vol. 45,# 2,p. 223 - 225] Location in patent:supporting information

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62-53-3 Synthesis