2-(2-THIENYL)-4H-3,1-BENZOXAZIN-4-ONE synthesis

10synthesis methods

Product Name:2-(2-THIENYL)-4H-3,1-BENZOXAZIN-4-ONE
CAS Number:26060-06-0
Molecular formula:C12H7NO2S
Molecular Weight:229.25

5271-67-0 Synthesis

5271-67-0
249 suppliers
$5.00/1g

118-92-3
4 suppliers
$23.00/250g

26060-06-0
23 suppliers
$28.60/5MG

Yield:26060-06-0 99%

Reaction Conditions:

with acetic anhydride;triethylamine in ethyl acetate;

Steps:

1 2-(2'-THIENYL)-4H-3,1-BENZOXAZIN-4-ONE

Example 1 2-(2'-THIENYL)-4H-3,1-BENZOXAZIN-4-ONE A solution of anthranilic acid (2.0 g, 15 mmol), 2-thienylcarbonyl chloride (2.2 g, 15 mmol), and triethylamine (1.5 g, 15 mmol) in ethyl acetate (9 mL) was stirred for 1 h. The solution was filtered and concentrated to a solid (3.7 g, 99%). The solid (1 g, 4 mmol) was heated at reflux with acetic anhydride (20 mL) for 18 h. The reaction mixture was concentrated, washed with water, and dried to give the title compound (0.92 g, 99%); m.p. 129-130° C.

References:

US5939421,1999,A

3437-95-4 Synthesis