ChemicalBook CAS DataBase List 2,4,6-Trichloroaniline

2,4,6-Trichloroaniline synthesis

14synthesis methods

Product Name:2,4,6-Trichloroaniline
CAS Number:634-93-5
Molecular formula:C6H4Cl3N
Molecular Weight:196.46

2,4,6-Trichloroaniline can be prepared by reaction of dry aniline with chlorine gas while in a anhydrous solution of carbon tetrachloride. 2,4,6-Trichloroaniline precipitates from solution as a white solid. If water is introduced to the solution the white material will polymerize to form aniline black.
Process for the preparation of 2,4,6-trichloroaniline

18708-70-8
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$12.00/1g

634-93-5
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$12.00/5g

Yield:634-93-5 97%

Reaction Conditions:

with hydrazine hydrate monohydrate in N,N-dimethyl-formamide at 100; for 6 h;Green chemistry;chemoselective reaction;

Steps:

Synthesis of amines; general procedure

General procedure: A mixture of the organic nitro compound (1.0 mmol), NH2NH2·H2O (2.5 equiv.) and H2O2-treated AC powder (50 wt%) in DMF (1.5 mL) was stirred vigorously magnetically at 100 °C. The reaction was monitored by LC-MS or GC-MS. On completion the reaction mixture was filtered to remove the catalyst. The combined organic mixture material was dried using anhydrous Na2SO4 and filtered. The solvent was removed under reduced pressure to obtain the products. All the compounds were known and characterised by their ¹H NMR and MS spectra and comparison with literature data.

References:

Jiang, Yuqin;Suo, Huajun;Zhang, Dandan;Li, Xiyong;Sun, Yamin;Ren, Baoqi;Zhang, Weiwei;Xu, Guiqing [Journal of Chemical Research,2017,vol. 41,# 9,p. 509 - 512]

62-53-3 Synthesis