2-(4-bromo-3-methylphenyl)acetonitrile synthesis
- Product Name:2-(4-bromo-3-methylphenyl)acetonitrile
- CAS Number:215800-25-2
- Molecular formula:C9H8BrN
- Molecular Weight:210.07
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Yield: 86%
Reaction Conditions:
in water;N,N-dimethyl-formamide at 20; for 4 h;Inert atmosphere;
Steps:
3 STEP-3: Preparation of 2-(4-bromo-3-methylphenyl)acetonitrile
NaCN (1.94 g, 39.77mmol, 1.5 eq) was added to the solution of 1-bromo-4-(bromomethyl)-2-methylbenzene (7.00 g, 26.51 mmol, 1.0 eq) in DMF and H20 (10:1, 100 mL) under nitrogen atmosphere and the solution was stirred at ambient temperature for 4 h. After complete consumption of startingmaterial, the reaction mixture was diluted with ice cold water and compound was extracted with diethyl ether. The organic extract was then washed with water, dried over anhydrous sodium sulfate, filtered, and solvent evaporated from the filtrated under reduced pressure to afford 2-(4- bromo-3-methylphenyl)acetonitrile as yellow oil (4.8 g, 86%).
References:
PORTOLA PHARMACEUTICALS, INC.;BARTA, Thomas, E.;BOURNE, Jonathna, William;MONROE, Kyle, D.;MUEHLEMANN, Michael, M.;PANDEY, Anjali;BOWERS, Simeon WO2017/34990, 2017, A1 Location in patent:Page/Page column 38
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