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2-[(4-chlorophenyl)amino]acetic acid synthesis

8synthesis methods
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Yield:5465-90-7 98%

Reaction Conditions:

Stage #1: N-(4-chlorophenyl)glycine ethyl esterwith lithium hydroxide monohydrate;lithium hydroxide monohydrate in tetrahydrofuran at 0 - 20;
Stage #2: with hydrogenchloride in tetrahydrofuran;lithium hydroxide monohydrate at 20; pH=3 - 4;

References:

Wu, Chunrui;Fang, Yuesi;Larock, Richard C.;Shi, Feng [Organic Letters,2010,vol. 12,# 10,p. 2234 - 2237] Location in patent:supporting information; experimental part

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