2,4-DIAMINO-6-NITROQUINAZOLINE synthesis
- Product Name:2,4-DIAMINO-6-NITROQUINAZOLINE
- CAS Number:7154-34-9
- Molecular formula:C8H7N5O2
- Molecular Weight:205.17
Yield: 71%
Reaction Conditions:
in N,N-dimethyl-formamide at 140; for 24 h;
Steps:
1.3 preparation of 6-nitro-metaphthyl-2,4-diamine (compound of formula IV)
To 0.73 g (10 mmol) Guanidine hydrochloride added 20 mL of N, N-dimethylformamide, 3.65 g (20 mmol) of 2-chloro-5-nitrobenzonitrile 140 ° C under the conditions of reaction 24h, Stop the reaction, Add appropriate amount of water, Extracted with ethyl acetate, Saturated salt washed organic phase, The organic phase was concentrated (solvent removed under reduced pressure) The residue was purified by silica gel column chromatography (eluent: methanol: dichloromethane = 1: 1, v / v) to give a white solid (compound of formula IV) in 71% yield.
References:
East China University of Science and Technology;Zhu Jin;Huang Jin;Chen Wenhua;Yao Xue;Ling Dazheng;Wang Manjiong;Jiang Hualiang;Li Jian CN106905247, 2017, A Location in patent:Paragraph 0062; 0063
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