ChemicalBook CAS DataBase List 2,4-DIAMINO-6-NITROQUINAZOLINE

2,4-DIAMINO-6-NITROQUINAZOLINE synthesis

4synthesis methods

Product Name:2,4-DIAMINO-6-NITROQUINAZOLINE
CAS Number:7154-34-9
Molecular formula:C8H7N5O2
Molecular Weight:205.17

16588-02-6
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$7.00/1g

50-01-1 Synthesis

50-01-1
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7154-34-9
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$47.00/1 G

Yield: 71%

Reaction Conditions:

in N,N-dimethyl-formamide at 140; for 24 h;

Steps:

1.3 preparation of 6-nitro-metaphthyl-2,4-diamine (compound of formula IV)
To 0.73 g (10 mmol) Guanidine hydrochloride added 20 mL of N, N-dimethylformamide, 3.65 g (20 mmol) of 2-chloro-5-nitrobenzonitrile 140 ° C under the conditions of reaction 24h, Stop the reaction, Add appropriate amount of water, Extracted with ethyl acetate, Saturated salt washed organic phase, The organic phase was concentrated (solvent removed under reduced pressure) The residue was purified by silica gel column chromatography (eluent: methanol: dichloromethane = 1: 1, v / v) to give a white solid (compound of formula IV) in 71% yield.

References:

East China University of Science and Technology;Zhu Jin;Huang Jin;Chen Wenhua;Yao Xue;Ling Dazheng;Wang Manjiong;Jiang Hualiang;Li Jian CN106905247, 2017, A Location in patent:Paragraph 0062; 0063

17420-30-3 Synthesis