2,4-Difluorophenyl acetic acid synthesis
- Product Name:2,4-Difluorophenyl acetic acid
- CAS Number:141060-00-6
- Molecular formula:C8H5ClF2O
- Molecular Weight:190.57
81228-09-3
260 suppliers
$12.00/2 g
141060-00-6
19 suppliers
$15.00/1g
Yield: 90.6%
Reaction Conditions:
with phosgene;4-(N,N-dipropylamino)pyridine in tolueneReflux;Reagent/catalyst;
Steps:
6 Example 6
Preparation of 2,4 - difluorophenylacetyl chloride catalyzed by dipropylaminopyridine in toluene
To the reaction flask was added 2,4-difluorophenylacetic acid 2 (^, toluene 20 (^, 4-dipropylaminopyridine 0.028,And the phosgene reaction was carried out under reflux condition, and the molar ratio of 2,4-difluorophenylacetic acid to phosgene was 1: 4, the phosgene was stopped, and the reaction was carried out under low vacuum After distilling off the toluene under reduced pressure, the product was distilled under reduced pressure under high vacuum to obtain 2,4-difluorophenylacetyl chloride, and the content was over 98% by chemical titration and the molar yield was 90.6%.
References:
Tianjin Jingxi Chemical Industry Limited Company;Peng, Jiuhe;Qiu, Xuenan;Lan, Xingfen CN105601502, 2016, A Location in patent:Paragraph 0055; 0056; 0057
79-37-8
460 suppliers
$17.67/10gm:
81228-09-3
260 suppliers
$12.00/2 g
141060-00-6
19 suppliers
$15.00/1g