ChemicalBook CAS DataBase List 2,4-Dimethyl-3-pentanol

2,4-Dimethyl-3-pentanol synthesis

6synthesis methods

Product Name:2,4-Dimethyl-3-pentanol
CAS Number:600-36-2
Molecular formula:C7H16O
Molecular Weight:116.2

565-80-0
134 suppliers
$9.00/1ml

600-36-2
116 suppliers
$14.00/1mL

Yield:600-36-2 97%

Reaction Conditions:

with C₂₈H₃₅ClCoN₅⁽¹⁺⁾*Cl^(1-);hydrogen;potassium hydroxide in tetrahydrofuran at 20; under 22502.3 Torr; for 16 h;Autoclave;

Steps:

General procedure for Hydrogenation of Ketones
General procedure: In an argon filled glove box, the cobalt catalyst (LNHC/CoCl2 or Co-2a) and the base wereweighted into a 4mL vial equipped with a magnetic stir bar, followed by addition of the solvent.After shaking of the vial for 30 seconds, the carbonyl substrate was then added. The vial wasplaced into a Parr Instruments autoclave, which was then sealed, removed from the glove boxand purged with hydrogen gas. The autoclave was heated to certain temperature. After reactionfor 16 hours, the autoclave was cooled down to 0 oC before releasing the hydrogen gas. Forquantitative GC analysis, biphenyl (1.0 mmol) as internal standard was added. The organiclayer was then filtrated and diluted for GC analysis. The stereo-selectivity of the hydrogenatedproducts of cyclohexanones were determined by NMR with mesitylene as the internal standard.The desired hydrogenation product was further isolated by flash column chromatography.

References:

Zhong, Rui;Wei, Zeyuan;Zhang, Wei;Liu, Shun;Liu, Qiang [Chem,2019,vol. 5,# 6,p. 1552 - 1566] Location in patent:supporting information

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