2-(4-HYDROXY-PIPERIDIN-1-YLMETHYL)-BENZONITRILE synthesis
1synthesis methods
- Product Name:2-(4-HYDROXY-PIPERIDIN-1-YLMETHYL)-BENZONITRILE
- CAS Number:887593-76-2
- Molecular formula:C13H16N2O
- Molecular Weight:216.28
Yield:887593-76-2 86%
Reaction Conditions:
with pyridine in tetrahydrofuran; for 1 h;Product distribution / selectivity;Heating / reflux;
Steps:
10
To a solution of 4-hydroxypiperidine (1.00 g, 0.01 mmol) and α-bromotolunitrile (2.91 g, 0.015 mmol) in 20 mL THF was added pyridine (1.62 mL, 0.02 mmol). The reaction mixture was heated to reflux for 1 hour. Solvents were removed under reduced pressure and the crude product purified by column chromatography (CH2Cl2/MeOH: 95/5) to give 1.86 g (86%) of the desired compound.
References:
US2009/23773,2009,A1 Location in patent:Page/Page column 55-56