2,5-Dihydro-2,5-dimethoxyfuran synthesis

Yield:332-77-4 85.3%

Reaction Conditions:

with triethylmethylammonium chloride;sodium carbonate at -5 - 5; for 10 h;

Steps:

1 Example 1
Into a reactor, 60 g of furan, 110 g of sodium carbonate, 2 g of methyltriethylammonium chloride as a phase-transfer catalyst and 300 g of methanol were charged and stirred,Open the low temperature thermostat bath cooling to -5 ~ 5°C , through chlorine 80g and maintain the reaction temperature, the reaction was completed after 10h reaction.The residual chlorine gas was withdrawn from the reaction solution under reduced pressure, allowed to stand (to make the solid-liquid layered), filtered (solid phase-transfer catalyst and salts removed), and the reaction solution was dried by adding an appropriate amount of anhydrous sodium sulfate for a while After filtration (sodium sulfate was removed), the filtrate was distilled under reduced pressure to give 97.6 g of product 2,5-dimethoxydihydrofuran in a yield of 85.3%.

References:

Jiangsu Qingquan Chemical Co., Ltd.;Zhu Ji;Pan Weiping;Zhang Hao;Xu Wei;Tian Guoxiong;Zhou Zeze;Dong Liang CN104592175, 2017, B Location in patent:Paragraph 0023; 0024

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