ChemicalBook CAS DataBase List 2,6-DICHLORO-4-METHOXY-PYRIDINE

2,6-DICHLORO-4-METHOXY-PYRIDINE synthesis

8synthesis methods

Product Name:2,6-DICHLORO-4-METHOXY-PYRIDINE
CAS Number:17228-75-0
Molecular formula:C6H5Cl2NO
Molecular Weight:178.02

67-56-1

16063-69-7

17228-75-0

To a solution of 2,4,6-trichloropyridine (3.64 g, 20.0 mmol) in DMF (20 mL) was slowly added NaH (60% dispersed in mineral oil, 840 mg, 21 mmol) and methanol (673 mg, 21 mmol) at 0 °C. The reaction mixture was stirred at room temperature for 16 hours. Upon completion of the reaction, the mixture was concentrated and partitioned between ethyl acetate (30 mL) and water (15 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated. The residue was purified by silica gel column chromatography to afford 2,6-dichloro-4-methoxypyridine (3.0 g, yield: 94%) using ethyl acetate (0-5%) in hexane as eluent.

67-56-1 Synthesis

67-56-1
790 suppliers
$7.29/5ml-f

16063-69-7 Synthesis

16063-69-7
218 suppliers
$40.00/5g

17228-75-0
121 suppliers
$17.00/250mg

Yield:17228-75-0 94%

Reaction Conditions:

with sodium hydride in N,N-dimethyl-formamide;mineral oil at 0 - 20; for 16 h;

Steps:

1 1. Preparation of 2, 6-dichloro-4-methoxypyridine
To a solution of 2,4,6-trichloropyridine (3.64 g, 20.0 mmol) in DMF (20 mL) at 0°C were slowly added NaH (60% in mineral oil, 840 mg, 21 mmol) and MeOH (673 mg, 21 mmol). The mixture was stirred at room temperature for 16 h. The mixture was concentrated and partitioned between EtOAc (30 mL) and water (15 mL). The organic extracts were dried (Na2SO4), filtered, and concentrated. The residue was purified by silica gel chromatography eluting with ethyl acetate in hexane (0-5 percent) to afford the title compound (3.0 g, yield: 94%).

References:

NEW ERA PHARMA, INC.;XIAN, Jun WO2018/106459, 2018, A1 Location in patent:Paragraph 00110

FullText

16063-69-7 Synthesis

16063-69-7
218 suppliers
$40.00/5g

124-41-4 Synthesis