2,6-DICHLORO-4-METHOXY-PYRIDINE synthesis
- Product Name:2,6-DICHLORO-4-METHOXY-PYRIDINE
- CAS Number:17228-75-0
- Molecular formula:C6H5Cl2NO
- Molecular Weight:178.02
67-56-1
776 suppliers
$7.29/5ml-f
16063-69-7
214 suppliers
$40.00/5g
17228-75-0
117 suppliers
$17.00/250mg
Yield:17228-75-0 94%
Reaction Conditions:
with sodium hydride in N,N-dimethyl-formamide;mineral oil at 0 - 20; for 16 h;
Steps:
1 1. Preparation of 2, 6-dichloro-4-methoxypyridine
To a solution of 2,4,6-trichloropyridine (3.64 g, 20.0 mmol) in DMF (20 mL) at 0°C were slowly added NaH (60% in mineral oil, 840 mg, 21 mmol) and MeOH (673 mg, 21 mmol). The mixture was stirred at room temperature for 16 h. The mixture was concentrated and partitioned between EtOAc (30 mL) and water (15 mL). The organic extracts were dried (Na2SO4), filtered, and concentrated. The residue was purified by silica gel chromatography eluting with ethyl acetate in hexane (0-5 percent) to afford the title compound (3.0 g, yield: 94%).
References:
NEW ERA PHARMA, INC.;XIAN, Jun WO2018/106459, 2018, A1 Location in patent:Paragraph 00110
16063-69-7
214 suppliers
$40.00/5g
124-41-4
716 suppliers
$12.00/25g
17228-75-0
117 suppliers
$17.00/250mg
67-56-1
776 suppliers
$7.29/5ml-f
25194-01-8
184 suppliers
$10.00/1g
17228-75-0
117 suppliers
$17.00/250mg
38608-87-6
4 suppliers
inquiry
17228-75-0
117 suppliers
$17.00/250mg
25194-01-8
184 suppliers
$10.00/1g
17228-75-0
117 suppliers
$17.00/250mg