2,6-DICHLORO-4-NITROANISOLE synthesis
- Product Name:2,6-DICHLORO-4-NITROANISOLE
- CAS Number:17742-69-7
- Molecular formula:C7H5Cl2NO3
- Molecular Weight:222.03
3107-19-5
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Yield: 98%
Reaction Conditions:
in methanol at 0 - 20; for 1.5 h;
Steps:
30.1; 31.1 Step 1: Example 30b
A mixture of Example 30a (2.1 g, 10 mmol) in MeOH (25 mL) was slowly added NaOMe (810 mg, 15 mmol) at 0°C. The reaction mixture was stirred at r.t. for 1.5 h. Water (50 mL) was added, and the mixture was extracted with EtOAc (100 mL*2). The combined organic layers were washed by brine (50 mL), separated, dried over Na2S04 and filtered. The solvent was removed in reduced pressure to give the desired product Example 30b (2.18 g, yield 98%) as a white solid. *HNMR (400 MHz, CDCl3) d 8.21 (s, 2H), 4.01 (s, 3H).
References:
FRONTHERA U.S. PHARMACEUTICALS LLC;JIN, Bohan;DONG, Qing;HUNG, Gene WO2019/240938, 2019, A1 Location in patent:Paragraph 00392; 00400
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17742-69-7
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20098-48-0
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17742-69-7
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124-41-4
726 suppliers
$12.00/25g
17742-69-7
135 suppliers
$28.00/1 g