ChemicalBook CAS DataBase List 2,6-Dihydroxybenzoic acid

2,6-Dihydroxybenzoic acid synthesis

11synthesis methods

Product Name:2,6-Dihydroxybenzoic acid
CAS Number:303-07-1
Molecular formula:C7H6O4
Molecular Weight:154.12

56-81-5 Synthesis

56-81-5
1612 suppliers
$5.00/25g

108-46-3 Synthesis

108-46-3
732 suppliers
$10.00/10g

303-07-1
411 suppliers
$10.00/5g

Yield:303-07-1 89%

Reaction Conditions:

with carbon dioxide at 100; for 24 h;

Steps:

1 (1) Preparation of intermediate 2-2
General procedure: The raw material 2-1 (100 mmol) was dissolved in 250 mL of glycerol, CO2 gas was introduced into the system, and reacted at 100 ° C for 24 h. After the reaction is complete, the system is poured into 1M dilute hydrochloric acid solution, and a large amount of solid is precipitated, sucked and dried to obtain intermediate 2-2. Specifically, when R1, R3 and R4 are both H, the yield of the obtained intermediate 2-2 is 89%. When R1 is CH3, and both R3 and R4 are H, the yield of intermediate 2-2 is 70%.

References:

Central China Normal University;Yang Guangfu;Qu Renyu;Xi Zhen;Chen Qiong;Chen Jie CN106831609, 2017, A Location in patent:Paragraph 0135; 0136; 0137; 0138

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