2-Amino-3-methoxy-5-methylpyrazine synthesis
- Product Name:2-Amino-3-methoxy-5-methylpyrazine
- CAS Number:89464-87-9
- Molecular formula:C6H9N3O
- Molecular Weight:139.16
67-56-1
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$9.00/25ml
124-41-4
716 suppliers
$12.00/25g
74290-65-6
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$25.00/100mg
89464-87-9
48 suppliers
$29.00/100mg
Yield:89464-87-9 92%
Reaction Conditions:
at 30 - 100; for 6 h;Inert atmosphere;
Steps:
35.2
[00791] To a mixture of 3-bromo-5-methyl-pyrazin-2-amine (31 g, 164.87 mmol) in MeOH (150 mL) was added NaOMe (14 g, 263.79 mmol) in one portion at 30 °C under N2. The mixture was stirred at 100 °C for 6 hrs. The mixture was concentrated under reduced pressure and the resulting residue was dissolved in water (100 mL). The mixture was extracted with EtOAc and the combined organic layers were washed with brine (20 mL), dried with Na2S04, filtered and concentrated under reduced pressure. The resulting residue was purified by column chromatography (to afford 3-methoxy-5-methyl-pyrazin-2-amine (21 g, 92% yield) as a white solid. 1H MR (400 MHz, CDCh-d) δ ppm 7.39 (s, 1H) 4.59 (br s, 2 H) 3.97 (s, 3 H) 2.29 (s, 3 H)
References:
WO2018/136265,2018,A1 Location in patent:Paragraph 00791
74290-65-6
118 suppliers
$25.00/100mg
89464-87-9
48 suppliers
$29.00/100mg
124-41-4
716 suppliers
$12.00/25g
74290-65-6
118 suppliers
$25.00/100mg
89464-87-9
48 suppliers
$29.00/100mg
5521-58-4
225 suppliers
$14.00/250mg
89464-87-9
48 suppliers
$29.00/100mg