ChemicalBook CAS DataBase List 2-Picolinic acid

2-Picolinic acid synthesis

11synthesis methods

Product Name:2-Picolinic acid
CAS Number:98-98-6
Molecular formula:C6H5NO2
Molecular Weight:123.11

2-Picolinic acid synthesis: In a 500ml three-necked flask, add 100g of 2-cyanopyridine and 200g of deionized water, then start stirring, heat up to 50°C, add 128.2g of 30% sodium hydroxide to the flask, after adding, add Continue to heat up, react under reflux for 4 hours, then distill water, after 50 g of distilled water, cool the reaction solution to 20°C, add 30% hydrochloric acid, adjust the pH value of the reaction solution to 2.5, then turn on the steam to heat up the water and steam to the kettle When the temperature reaches 120°C, the reaction solution is evaporated to dryness, and the distilled water is completed. Then, 300 g of anhydrous alcohol is added dropwise to the flask to maintain the temperature of the reaction solution at 55°C. After cooling and crystallization, a solid was precipitated, filtered and dried to obtain 106.0 g of 2-picolinic acid with a yield of 89.6%.

586-98-1 Synthesis

586-98-1
410 suppliers
$6.00/10g

98-98-6
595 suppliers
$5.00/10g

Yield:98-98-6 97%

Reaction Conditions:

with tert-butyldimethylsilyl chloride in methanol;water at 20; for 0.5 h;Green chemistry;

Steps:

Synthesis of carboxylic acids pyridine-2-carboxylic acid (7), thiophene-2-carboxylic acid (8) or furan-2-carboxylic acid (9)

An appropriate alcohol [2-pyridinemethanol (3) (1.0 g, 9.20 mmol, 1 eq), 2-thiophenemethanol (4) (1.0 g, 8.78 mmol, 1 eq) or 2-furanmethanol (5) (1.0 g,10.20 mmol] was added to reaction mixture that contained Ag/ZnO/graphene nanocomposite (10 mg, 1 wt%), and TBSCl (1.38 g, 9.20 mmol, 1 eq), (1.32 g, 8.78 mmol, 1 eq), (1.53 g, 10.20 mmol, 1 eq) or (1.38 g, 9.26 mmol, 1 eq) dissolved in MeOH:H2O (1:1, 10 mL). The mixture was stirred for 30, 60 or 60 min, respectively, at room temperature and monitored by TLC using eluent system (EtOAc:Hexane, 3:7). The mixture was filtrated and then water (5 mL) was added, and the mixture was extracted with (CHCl3: MeOH, 1:1) (5 mL * 2). The collected methanol/water layer was evaporated using rotary evaporator to afford the residue that was purified by column chromatography using silica gel (Hexane:EtOAc, 7:3, 6:4 and then 1:1) to afford the corresponding carboxylic acids; pyridine-2-carboxylic acid (7); thiophene-2-carboxylic acid (8) or furan-2-carboxylicacid (9) respectively.

References:

Attia, Yasser A.;Vázquez, Carlos Vázquez;Mohamed, Yasser M. A. [Research on Chemical Intermediates,2017,vol. 43,# 1,p. 203 - 218]

100-70-9 Synthesis

100-70-9
406 suppliers
$13.00/25g

98-98-6
595 suppliers
$5.00/10g

References

2-Pyridinemethanol, α-[2-(4-methoxyphenyl)cyclopropyl]-

1309453-54-0
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98-98-6
595 suppliers
$5.00/10g

[2-(4-METHOXYPHENYL)CYCLOPROPYL](2-PYRIDINYL)METHANONE

338415-92-2
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100-09-4 Synthesis

100-09-4
610 suppliers
$6.00/25g

References

109-06-8
395 suppliers
$16.00/25g

98-98-6
595 suppliers
$5.00/10g

References

1121-60-4
496 suppliers
$10.60/10gm:

98-98-6
595 suppliers
$5.00/10g

References

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