ChemicalBook CAS DataBase List 2-AMINO-5-(4-NITROPHENYL)-1 3 4-THIADIA&

2-AMINO-5-(4-NITROPHENYL)-1 3 4-THIADIA& synthesis

12synthesis methods

Product Name:2-AMINO-5-(4-NITROPHENYL)-1 3 4-THIADIA&
CAS Number:833-63-6
Molecular formula:C8H6N4O2S
Molecular Weight:222.22

79-19-6
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$14.00/1g

62-23-7 Synthesis

62-23-7
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2-AMINO-5-(4-NITROPHENYL)-1 3 4-THIADIA&

833-63-6
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$45.00/100mg

Yield:833-63-6 90%

Reaction Conditions:

with trichlorophosphate at 75; for 0.5 h;

Steps:

General Procedure for Preparing 5-substituted-1,3,4-thiadiazol-2-amine.

General procedure: A stirring mixture of benzoic acid (7.32 g, 60 mmol), N-aminothiourea(6.38 g, 70 mmol) and POCl3 (20 ml) washeated at 75 °C for 0.5 h. After cooling down to room temperature,water was added. The reaction mixture was refluxedfor 4 h. After cooling, the mixture was basified to pH8 by the drop-wise addition of 50% NaOH solution understirring. The precipitate was filtered and re-crystallized from ethanol

References:

Tu, Guo Gang;Zhan, Jian Feng;Lv, Qiao Li;Wang, Jia Qi;Kuang, Bin Hai;Li, Shao Hua [Medicinal Chemistry,2014,vol. 10,# 4,p. 376 - 381]