2-Amino-5-chlorobenzoic acid synthesis
- Product Name:2-Amino-5-chlorobenzoic acid
- CAS Number:635-21-2
- Molecular formula:C7H6ClNO2
- Molecular Weight:171.58
2516-95-2
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635-21-2
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Yield:635-21-2 96%
Reaction Conditions:
with hydrogen;nickel in ethanol at 20;
Steps:
3 Preparation of 2-Amino-5-chloro benzoic acid (Compound 57)
To a solution of 5-chloro-2-nitrobenzoic acid (20 g, 110 mmol) in ethanol was added freshly activated raney nickel (2 g). The mixture was stirred overnight at room temperature under hydrogen atmosphere. The solution was filtered through celite and evaporated under reduced pressure to yield 16 g (96%) of white SOLIDS. 1H NMR (DMSO-D6) : d 6.77 (d, J = 8.9 Hz, 1H), 7.24 (DD, J= 2.9, 8.9 Hz, 1H), 7.62 (d, J= 2.9 Hz, 1H), 8.7 (b, 3H); EIMS: 170 (M-H).
References:
AVANIR PHARMACEUTICALS WO2004/74218, 2004, A2 Location in patent:Page 115-116
88279-11-2
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635-21-2
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17422-32-1
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21739-93-5
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635-21-2
425 suppliers
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