ChemicalBook CAS DataBase List 2-AMINO-5-FLUOROACETOPHENONE

2-AMINO-5-FLUOROACETOPHENONE synthesis

8synthesis methods

Product Name:2-AMINO-5-FLUOROACETOPHENONE
CAS Number:2343-25-1
Molecular formula:C8H8FNO
Molecular Weight:153.15

600 g of 2-ethynyl-4-fluoroaniline and 4 L of water were added to the reaction flask, and then 476 g of hydrochloric acid (concentration: 35%) was added, and thereaction was carried out at 50 °C for 36 hours.After the reaction, the temperature is lowered to 20-25 °C, the reaction solution is adjusted to pH 8-9 with 50% sodium hydroxide solution, thetemperature is controlled to not exceed 30 °C during pH adjustment, and the filter cake is washed with 1 L of water and decompressed at 50 °C. After drying for 12 h, 622 g of pale yellow solid was obtained, yield91.4%.HPLC purity was 99.2%.

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2343-25-1
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Yield: 91.4%

Reaction Conditions:

with hydrogenchloride;water at 50; for 36 h;Green chemistry;Temperature;Reagent/catalyst;

Steps:

8
600 g of 2-ethynyl-4-fluoroaniline and 4 L of water were added to the reaction flask, and then 476 g of hydrochloric acid (concentration: 35%) was added, and thereaction was carried out at 50 °C for 36 hours.After the reaction, the temperature is lowered to 20-25 °C, the reaction solution is adjusted to pH 8-9 with 50% sodium hydroxide solution, thetemperature is controlled to not exceed 30 °C during pH adjustment, and the filter cake is washed with 1 L of water and decompressed at 50 °C. After drying for 12 h, 622 g of pale yellow solid was obtained, yield91.4%.HPLC purity was 99.2%.

References:

Hangzhou Keyao Pharmaceutical Technology Co., Ltd.;Zhou Junming CN109384683, 2019, A Location in patent:Paragraph 0026-0042

351-83-7 Synthesis