2-AMINO-5-FLUOROPHENYL BORONIC ACID PINACOL ESTER synthesis
- Product Name:2-AMINO-5-FLUOROPHENYL BORONIC ACID PINACOL ESTER
- CAS Number:863578-24-9
- Molecular formula:C12H17BFNO2
- Molecular Weight:237.08
1003-98-1
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73183-34-3
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863578-24-9
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Yield: 60%
Reaction Conditions:
with (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;potassium acetate in 1,4-dioxane for 10 h;Reflux;
Steps:
3.1.1-6
To a two-neck flask, add 2-bromo-4-fluoroaniline (11 g, 57.9 mmol) and dissolve in dioxane (300 mL). Potassium acetate (23 g, 231.6 mmol) and Pd (dppf) 2.9 mmol). After 5 minutes, add Bis (pinacolato) diboron (19.12 g, 75.3 mmol) and reflux for 10 hours. When the reaction is complete, extract with CH2Cl2. Purification by silica gel column (yield: 60%)
References:
Consideration University Sejong Industry-Academic Cooperation Foundation;Lee Seung-jun;Kang Sang-uk;Son Ho-jin KR2018/50795, 2018, A Location in patent:Paragraph 0134; 0135; 0156-0158
1003-98-1
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25015-63-8
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863578-24-9
36 suppliers
$48.00/100mg
371-40-4
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863578-24-9
36 suppliers
$48.00/100mg