2-bromo-1-iodo-4-methoxybenzene synthesis
- Product Name:2-bromo-1-iodo-4-methoxybenzene
- CAS Number:466639-53-2
- Molecular formula:C7H6BrIO
- Molecular Weight:312.93
32338-02-6
136 suppliers
$14.00/1g
466639-53-2
106 suppliers
$9.00/250mg
Yield: 92%
Reaction Conditions:
Stage #1:2-bromo-4-methoxyaniline with hydrogenchloride;sodium nitrite in water;acetonitrile at 0 - 5; for 0.5 h;Sandmeyer Reaction;
Stage #2: with potassium iodide in water;acetonitrile at 20;Sandmeyer Reaction;
Steps:
1) 2-bromoiodobenzene (2a) as general procedure
General procedure: To a solution of 2-bromoaniline (5 g, 29 mmol) dissolved in CH3CN (80 mL) was added aq. HCl (15 mL conc. HCl in 50 mL water), then the mixture was cooled to 0 °C, and it was added a solution of NaNO2 (2.4 g, 34.87 mmol) in water (50 mL). After addition, the reaction was kept at the temperature lower than 5 °C for 30 min and it was added a solution of (7.23 g, 43.59 mmol) in water (50 mL). After addition, the reaction was kept at room temperature overnight, poured into water (300 mL) and extracted with CH2Cl2.The organic phase was dried over MgSO4. After workup, the brown oily product was distilled to afford a pale-yellow.
References:
Lv, Jun;Liu, Qiancai;Tang, Jie;Perdih, Franc;Kranjc, Kristof [Tetrahedron Letters,2012,vol. 53,# 39,p. 5248 - 5252] Location in patent:supporting information
2398-37-0
584 suppliers
$8.00/10g
466639-53-2
106 suppliers
$9.00/250mg
2398-37-0
584 suppliers
$8.00/10g
466639-53-2
106 suppliers
$9.00/250mg
791642-68-7
118 suppliers
$10.00/250mg
100-02-7
34 suppliers
$11.00/5G
466639-53-2
106 suppliers
$9.00/250mg
20455-07-6
3 suppliers
inquiry
466639-53-2
106 suppliers
$9.00/250mg