ChemicalBook CAS DataBase List 2-Bromo-5-fluorobenzotrifluoride

2-Bromo-5-fluorobenzotrifluoride synthesis

7synthesis methods

Product Name:2-Bromo-5-fluorobenzotrifluoride
CAS Number:40161-55-5
Molecular formula:C7H3BrF4
Molecular Weight:243

392-83-6 Synthesis

392-83-6
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Benzoic acid, 4-(methoxymethoxy)-, ethyl ester

5942-30-3
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Yield:5942-30-3 96.7%

Reaction Conditions:

with potassium fluoride;potassium tetrafluorocobaltate in dimethyl sulfoxide; for 5 h;Reflux;

Steps:

1-7

Add 2-bromobenzotrifluoride (2.3g), DMSO (60mL), potassium fluoride (2.5g) and KCoF4 (7.0g) in a 100mL flask, and carry out the reaction under heating and reflux for 5 hours. After evaporating part of the solvent 100 mL of water was added, followed by extraction with dichloromethane, and column chromatography to obtain 2.4 g of 2-bromo-5-fluorobenzotrifluoride with a yield of 96.7%.

References:

CN111362775,2020,A Location in patent:Paragraph 0025; 0027-0028; 0030-0031; 0033-0034; 0036-0037

401-80-9 Synthesis