ChemicalBook CAS DataBase List 2-Bromobenzotrifluoride

2-Bromobenzotrifluoride synthesis

14synthesis methods

Product Name:2-Bromobenzotrifluoride
CAS Number:392-83-6
Molecular formula:C7H4BrF3
Molecular Weight:225.01

88-17-5 Synthesis

88-17-5
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$14.00/25g

392-83-6
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$6.00/10g

Yield:392-83-6 89%

Reaction Conditions:

Stage #1:2-(trifluoromethyl)benzenamine with hydrogen bromide;sodium nitrite in water at 0 - 5; for 0.333333 h;
Stage #2: with hydrogen bromide;copper(I) bromide in water at 20; for 0.333333 h;Sandmeyer Reaction;

Steps:

2.1 (1) Sandemeyer bromination reaction
While stirring slowly, 308 g (1.9 mol) of o-trifluoromethylaniline was added to 970 mL of hydrobromic acid (40%) with stirring After cooling with ice bath to 0 ° C. 140 g (2.03 mol) of sodium nitrite was dissolved in 325 mL of water and slowly added dropwise with stirring Reaction system, and the reaction temperature does not exceed 5 ° C. After dripping, continue stirring for 20 min, keep warm. To 2 L four mouth The flask was charged with 23.5 g (0.34 mol) of cuprous bromide, 65 mL of hydrobromic acid (40%), stirred vigorously at room temperature, and the above diazonium Poured into the four reaction bottles, the reaction has a large amount of gas generated, the diazonium solution added after the continuous stirring 20 min, liquid, the lower The substrate was washed with alkali and washed with water. The product was simply distilled to obtain a yellow liquid product o-bromotrifluorotoluene 386 g, GC content: 99% yield: 89%. The upper aqueous phase is recyclable with hydrobromic acid and cuprous bromide.

References:

Zhejiang Weihua Chemical Co., Ltd.;Chen Jinghua;Wu Jiangwei;Bu Luzhou;Li Junqi;Chang Xuanchao;Zhang Quanquan;Zhao Hongying CN106905104, 2017, A Location in patent:Paragraph 0020

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