2-broMo-6-(naphthalen-2-yl)naphthalene synthesis
- Product Name:2-broMo-6-(naphthalen-2-yl)naphthalene
- CAS Number:62156-75-6
- Molecular formula:C20H13Br
- Molecular Weight:333.22
13720-06-4
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Yield:62156-75-6 93%
Reaction Conditions:
with potassium carbonate;tetrakis-(triphenylphosphine)-palladium in tetrahydrofuran; for 24 h;Heating / reflux;Suzuki Coupling;
Steps:
7.7-A
7- A . Production of compound 7a; [119] After 2,6-dibromonaphthalene (5 g, 17.48 mmol) and 2-naphthalene bromic acid (1.5 g, 8.74 mmol) were dissolved in anhydrous THF (100 mL), Pd(PPh ) (0.3 g, 0.263 4 mmol) and 50 mL of 2M K CO aqueous solution were added and then refluxed for 24 hours. The organic layer was extracted by using ethyl acetate and water was removed with magnesium sulfate. The organic layer was filtered at reduced pressure and concentrated, and the solvent was removed. The resulting substance was purified by using column chromatography and then recrystallized in THF and ethanol to obtain a white solid compound 7a (2.7 g, 93%).[120] MS [M + H] = 283
References:
WO2008/13399,2008,A1 Location in patent:Page/Page column 18
32316-92-0
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$6.00/1g
151600-02-1
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62156-75-6
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