2-Bromo-7-iodofluorene synthesis
- Product Name:2-Bromo-7-iodofluorene
- CAS Number:123348-27-6
- Molecular formula:C13H8BrI
- Molecular Weight:371.01
1133-80-8
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123348-27-6
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Yield:123348-27-6 98%
Reaction Conditions:
with potassium iodate;sulfuric acid;iodine;acetic acid in water at 80; for 12 h;Inert atmosphere;
Steps:
7 Example 7, Synthesis of 2-bromo-7-iodo-9H-fluorene (8)
2-bromoindole (2.44 g, 10 mmol), iodine (1.1 g, 4.5 mmol) and potassium iodate (0.65 g, 3 mmol) were dissolved in a mixed solvent (45 ml of glacial acetic acid, 5 ml of water and 2 ml of sulfuric acid). Under nitrogen protection, the reaction system was heated to 80 ° C for 12 h. After the reaction was completed, the reaction system was slowly cooled to room temperature, extracted with 10 ml of dichloromethane, and washed with water until neutral. The organic layer was dried over anhydrous sodium sulfate and filtered.The filtrate is recovered under reduced pressure,Residue column chromatography gave a white solid 3.63 g, yield 98%.
References:
CN109678686,2019,A Location in patent:Paragraph 0071-0073
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