2-(Trifluoromethyl)benzoic acid synthesis
- Product Name:2-(Trifluoromethyl)benzoic acid
- CAS Number:433-97-6
- Molecular formula:C8H5F3O2
- Molecular Weight:190.12
447-61-0
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433-97-6
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$10.00/5g
Yield:433-97-6 92%
Reaction Conditions:
with tris[2-(4,6-difluorophenyl)pyridinato-C2,N]-iridium(III);oxygen in acetonitrile at 20;Irradiation;Sealed tube;Green chemistry;chemoselective reaction;
Steps:
Synthesis of carboxylic acids
General procedure: An oven-dried resealable test tube equipped with a magnetic stir bar was charged withaldehyde (1.0 mmol), Ir(dFppy)3 (0.005-0.01 mmol), and MeCN (4.0 mL, 0.25 M). Oxygen wasthen bubbled through the reaction mixture and sealed with a silicone septa screw-cap. A balloonfilled with oxygen was attached to the tube, and the test tube was placed under blue LEDs atroom temperature. The reaction was allowed to proceed for 3-12 h, and reaction progress waschecked by TLC. The solvent was removed under vacuum, and the corresponding carboxylic acidwas purified by flash silica gel chromatography.
References:
Iqbal, Naeem;Choi, Sungkyu;You, Youngmin;Cho, Eun Jin [Tetrahedron Letters,2013,vol. 54,# 46,p. 6222 - 6225] Location in patent:supporting information
201230-82-2
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392-83-6
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344-96-7
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433-97-6
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$10.00/5g
312-96-9
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433-97-6
344 suppliers
$10.00/5g