2-Chloro-1,3-dimethylimidazolidinium chloride synthesis
- Product Name:2-Chloro-1,3-dimethylimidazolidinium chloride
- CAS Number:37091-73-9
- Molecular formula:C5H10Cl2N2
- Molecular Weight:169.05
80-73-9
37091-73-9
General procedure for the synthesis of 2-chloro-1,3-dimethylimidazolium chloride from 1,3-dimethyl-2-imidazolidinone: In a 1000 ml three-necked reaction flask, 1,3-dimethyl-2-imidazolidinone (34.2 g, 0.3 mol) and carbon tetrachloride (400 ml) were added. A carbon tetrachloride solution of solid phosgene (containing 30 g of solid phosgene, 0.1 mole, dissolved in 100 mL of carbon tetrachloride) was added slowly and dropwise. The temperature of the reaction mixture was controlled below 5°C with vigorous stirring for 0.5 hours. Subsequently, the reaction mixture was brought to room temperature and the reaction was continued for 1 hour. Next, it was heated to 50°C and kept at this temperature for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature, filtered, and washed with a small amount of carbon tetrachloride to afford 49 g of a pure white crystalline product, 2-chloro-1,3-dimethylimidazolium chloride, in 96.6% yield.
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37091-73-9
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Yield:37091-73-9 96.6%
Reaction Conditions:
with phosgene in tetrachloromethane at 5 - 50; for 5.5 h;
Steps:
preparation of chloro-1,3-dimethyl-2-chloroimidazoline
For 1000 ml three port in the reaction bottle, by adding 1,3-dimethyl-2-imidazolidinone (34.2 g, 0.3 mol), carbon tetrachloride (400 ml), stirring slowly dropwise solid phosgene carbon tetrachloride solution (containing solid phosgene 30 g, 0.1 mole, carbon tetrachloride 100 ml), the reaction mixture is kept below 5 °C, violent mixing 0.5 hours, the reaction at room temperature 1 hour, heating to 50 °C, maintain 4 hours. To be the reaction product is cooled to room temperature, filter, a small amount of carbon tetrachloride washing, get a pure white crystalline product chloropivaloyl 1,3-dimethyl-2-chlorotrifluoromethylbenzene imidazoline 49 g, yield of 96.6%,
References:
Beijing Chengyu Pharmaceutical Co., Ltd.;Song, Ye;Wang, Daolin;Wang, Yuping CN105367478, 2016, A Location in patent:Paragraph 0021; 0027; 0028
80-73-9
596 suppliers
$8.00/25g
79-37-8
489 suppliers
$17.67/10gm:
37091-73-9
213 suppliers
$7.00/1g