2-CHLORO-3-(TRIMETHYLSILYL)PYRIDINE synthesis
- Product Name:2-CHLORO-3-(TRIMETHYLSILYL)PYRIDINE
- CAS Number:77332-76-4
- Molecular formula:C8H12ClNSi
- Molecular Weight:185.73
Yield:77332-76-4 95%
Reaction Conditions:
Stage #1: 2-chloropyridinewith 2,2,6,6-tetramethyl-piperidine;n-butyllithium in tetrahydrofuran;hexane at -78; for 1.5 h;
Stage #2: chloro-trimethyl-silane in tetrahydrofuran;hexane at -78 - -10;
References:
Gros, Philippe;Choppin, Sabine;Fort, Yves [Journal of Organic Chemistry,2003,vol. 68,# 6,p. 2243 - 2247]
52200-48-3
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77332-76-4
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