2-Chloro-4-nitroimidazole synthesis
- Product Name:2-Chloro-4-nitroimidazole
- CAS Number:57531-37-0
- Molecular formula:C3H2ClN3O2
- Molecular Weight:147.52
16265-04-6
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57531-37-0
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$7.00/100mg
Yield:57531-37-0 87.3%
Reaction Conditions:
Stage #1:2-chloro-1H-imidazole with sulfuric acid at 20; for 0.5 h;
Stage #2: with sulfuric acid;nitric acid at 45 - 110; for 1 h;
Steps:
1
4 g of 98% sulfuric acid, 2.04 g of 2-chloroimidazole ((? 02 mol) was added to the three-necked flask, and the mixture was stirred at room temperature (? 5h,And then heated to 45 ~ 55 ° C, slowly dropping from 1. 9g95% fuming nitric acid (0. 03mol) and 5g 20% fuming sulfuric acid composition of the mixed acid, after dropping, the temperature to 110 ° C reaction lh, the end After the reaction solution was poured into ice water, the pH was adjusted to 3 to 4 with aqueous ammonia, filtered and the cake was dried to give a white powdery solid 2-chloro-4-nitroimidazole, 56 mg, yield 87.3% HPLC purity 99. 4%, melting point 218. 6 ~ 219.5 ° C.
References:
Yancheng Institute Of Technology;Zhao, LingLing;Dai, Yong;Qi, gang CN103396369, 2016, B Location in patent:Paragraph 0020; 0023
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57531-37-0
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5213-49-0
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65902-59-2
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57531-37-0
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