ChemicalBook CAS DataBase List 2-Chloro-6-methoxypyridine-3-carbonitrile

2-Chloro-6-methoxypyridine-3-carbonitrile synthesis

4synthesis methods

Product Name:2-Chloro-6-methoxypyridine-3-carbonitrile
CAS Number:121643-47-8
Molecular formula:C7H5ClN2O
Molecular Weight:168.58

124-41-4 Synthesis

124-41-4
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40381-90-6 Synthesis

40381-90-6
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$6.00/250mg

2-Chloro-6-methoxypyridine-3-carbonitrile

121643-47-8
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Yield:121643-47-8 675 mg

Reaction Conditions:

in methanol at 15; for 16 h;

Steps:

313.A A) 2-chloro-6-methoxynicotinonitrile

To a solution of 2,6-dichloronicotinonitrile (2.50 g) in MeOH (65 mL) was added slowly a solution of NaOMe (781 mg) in MeOH (15 mL).
The mixture was stirred at 15° C. for 16 hr.
The mixture was concentrated under reduced pressure.
The residue was diluted with EtOAc, washed with water and brine, dried over Na₂SO₄ and concentrated under reduced pressure.
The residue was purified by silica gel column chromatography (EtOAc/PE) to give the titled compound (675 mg).
¹H NMR (400 MHz, CDCl₃) δ 7.79 (d, J=8.4 Hz, 1H), 6.76 (d, J=8.8 Hz, 1H), 4.01 (s, 3H); MS m/z 169.1 [M+H]⁺.

References:

US2022/98207,2022,A1 Location in patent:Paragraph 1906-1907

67-56-1 Synthesis