2-Chloro-7-Methoxyquinoline synthesis
- Product Name:2-Chloro-7-Methoxyquinoline
- CAS Number:49609-15-6
- Molecular formula:C10H8ClNO
- Molecular Weight:193.63
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Yield:49609-15-6 98%
Reaction Conditions:
with trichlorophosphate for 3 h;Reflux;
Steps:
29.3 Step 3.2-Chloro-7-methoxyquinoline
300 mg (1.9 mmol) of 7-methoxyquinolin-2(1H)-one was dissolved in 1.1 mL of POCl3 (12 mmol) and heated at reflux for 3 h. The mixture was poured into iced water, neutralized with sat NaHCO3 and extracted with ethyl acetate. Yield 98%.1H NMR (400 MHz, CDCl3) δ 8.01 (d, J = 8.5 Hz, 1H), 7.68 (d, J = 8.9 Hz, 1H), 7.35 (d, J = 2.4 Hz, 1H), 7.25 (d, J = 8.3 Hz, 1H), 7.20 (dd, J = 8.9, 2.5 Hz, 1H), 3.93 (s, 3H).
References:
WO2016/130968,2016,A1 Location in patent:Page/Page column 183-184
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49609-15-6
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536-90-3
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$10.00/5g
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15116-41-3
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