2-CHLOROPYRIMIDINE-5-BORONIC ACID synthesis
- Product Name:2-CHLOROPYRIMIDINE-5-BORONIC ACID
- CAS Number:1003845-06-4
- Molecular formula:C4H4BClN2O2
- Molecular Weight:158.35
5419-55-6
363 suppliers
$12.00/5g
32779-36-5
612 suppliers
$5.00/5g
1003845-06-4
184 suppliers
$18.69/250mg
Yield:1003845-06-4 73.3%
Reaction Conditions:
with hydrogenchloride;n-butyllithium in tetrahydrofuran;hexane;toluene at -78; for 4 h;
Steps:
25.1 Step 1: Synthesis of 2-chloropyrimidin-5-yl-5-boronic acid
Step 1:
Synthesis of 2-chloropyrimidin-5-yl-5-boronic acid
To a stirred solution of 5-bromo-2-chloropyrimidine (1.0 g, 5.170 mmol) in mixture of THF:Toluene (25 mL, 4:1) was added n-BuLi (1.6M in Hexane) (3.87 mL, 5.61 mmol) dropwise at -78° C.
And allowed to stir at -78° C. for 4 h.
On completion, Reaction mass diluted with water and stirred at RT for 1 h, extracted with Diethyl ether.
Then acidify using 1N HCl up to pH 2-3and extracted with EtOAc.
Organic portions were combined, dried over Na2SO4, evaporated under reduced pressure to give 2-chloropyrimidin-5-yl-5-boronic acid (0.6 g, 73.3%) as white solid.
MS: 159.3[M++1]
References:
Mankind Pharma Ltd.;Patil, Rakesh Ishwar;Verma, Jeevan;Shah, Dharmesh;Ali, Sazid;Bapuram, Srinivasa Reddy;Rai, Santosh Kumar;Kumar, Anil US2017/291910, 2017, A1 Location in patent:Paragraph 0508-0510
32779-36-5
612 suppliers
$5.00/5g
1003845-06-4
184 suppliers
$18.69/250mg